Efficient encoding and decoding of data for storage in polymers is provided. In various embodiments, an input file is read. The input file is segmented into a plurality of segments. A plurality of packets is generated from the plurality of segments by applying a fountain code. Each of the plurality of packets is encoded as a sequence of monomers. The sequences of monomers are screened against at least one constraint. An oligomer is outputted corresponding to each sequence that passes the screening.