Invention Grant
- Patent Title: Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities
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Application No.: US15662180Application Date: 2017-07-27
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Publication No.: US10738096B2Publication Date: 2020-08-11
- Inventor: K. Christopher Garcia , Darren L. Bates , Ignacio Moraga
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/16 ; C07K14/54 ; C07K14/52
Abstract:
Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (IL-4) muteins. The disclosed methods encompass administering an IL-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population.
Public/Granted literature
- US20180016316A1 SUPERKINES AND SYNTHEKINES: REPURPOSED CYTOKINES WITH NEW AND ENHANCED SIGNALING ACTIVITIES Public/Granted day:2018-01-18
Information query
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