Invention Grant
- Patent Title: Prodrugs of glutamine analogs
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Application No.: US16454880Application Date: 2019-06-27
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Publication No.: US10738066B2Publication Date: 2020-08-11
- Inventor: Barbara Slusher , Rana Rais , Lukas Tenora , Pavel Majer , Andrej Jancarik
- Applicant: THE JOHNS HOPKINS UNIVERSITY , Ústav organické chemi a biochemie AV {hacek over (C)}R, v.v.i.
- Applicant Address: US MD Baltimore CZ Prague
- Assignee: The Johns Hopkins University,Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i.
- Current Assignee: The Johns Hopkins University,Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i.
- Current Assignee Address: US MD Baltimore CZ Prague
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07D209/18
- IPC: C07D209/18 ; C07F9/24 ; A61K31/404 ; C07D317/40 ; C07C227/14 ; C07F9/6561 ; C07C271/22 ; C07C245/18 ; C07D473/34 ; C07D209/20 ; C07D211/90 ; C07H15/203 ; C07H19/207 ; C07D263/18 ; A61P35/00 ; C07D263/04 ; C07D309/10 ; C07D317/38 ; C07K5/062 ; C07K5/078 ; C07K5/083 ; A61K38/00
Abstract:
The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
Public/Granted literature
- US20190315784A1 PRODRUGS OF GLUTAMINE ANALOGS Public/Granted day:2019-10-17
Information query
