![N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-D]pyrimidin-1-YL]-phenyl}-cyclopropanecarboxamide dimethyl sulfoxide solvate as an MEK1/2 inhibitor](/docs/US/2020-08-11/US10738049B2/abs.jpg.600x600.jpg)
- Patent Title: N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-D]pyrimidin-1-YL]-phenyl}-cyclopropanecarboxamide dimethyl sulfoxide solvate as an MEK1/2 inhibitor
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Application No.: US16340874Application Date: 2016-12-12
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Publication No.: US10738049B2Publication Date: 2020-08-11
- Inventor: Alexandre Vasilievich Ivachtchenko , Alexey Evgenievich Repik , Vasily Gennadievich Ignatiev , Mikhail Airatovich Chafeev
- Applicant: R-PHARM JOINT STOCK COMPANY (R-PHARM, JSC) , Alexey Evgenievich Repik
- Applicant Address: RU Moscow
- Assignee: R-PHARM JOINT STOCK COMPANY (R-PHARM, JSC)
- Current Assignee: R-PHARM JOINT STOCK COMPANY (R-PHARM, JSC)
- Current Assignee Address: RU Moscow
- Agency: Kolisch Hartwell, P.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3f862c9
- International Application: PCT/RU2016/000862 WO 20161212
- International Announcement: WO2018/070900 WO 20180419
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D471/04 ; A61P35/00
![N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-D]pyrimidin-1-YL]-phenyl}-cyclopropanecarboxamide dimethyl sulfoxide solvate as an MEK1/2 inhibitor](/abs-image/US/2020/08/11/US10738049B2/abs.jpg.150x150.jpg)
Abstract:
Novel MEK1, MEK2 and MEK1/2 inhibitors which have lower toxicity in long-term dosage, including the novel compound N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropanecarboxamide dimethyl sulfoxide solvate according to formula 1:
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