- Patent Title: Modulators of cystic fibrosis transmembrane conductance regulator
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Application No.: US16089703Application Date: 2017-03-31
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Publication No.: US10738030B2Publication Date: 2020-08-11
- Inventor: Brian Bear , Jeremy Clemens , Thomas Cleveland , Timothy Richard Coon , Peter Diederik Jan Grootenhuis , Bryan A. Frieman , Sara S. Hadida Ruah , Haripada Khatuya , Paul J. Krenitsky , Mark Thomas Miller , Alina Silina , Johnny Uy , Jinglan Zhou
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- International Application: PCT/US2017/025381 WO 20170331
- International Announcement: WO2017/173274 WO 20171005
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D213/82 ; A61P11/00 ; C07D401/12 ; C07D471/04
Abstract:
The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.
Public/Granted literature
- US20190055220A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Public/Granted day:2019-02-21
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