Invention Grant
- Patent Title: Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
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Application No.: US15521149Application Date: 2015-10-22
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Publication No.: US10736974B2Publication Date: 2020-08-11
- Inventor: Martin G. Pomper , Ronnie C. Mease , Sangeeta Ray , Ying Chen , Xing Yang
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Casimir Jones, S.C.
- Agent Jeffrey W. Childers
- International Application: PCT/US2015/056909 WO 20151022
- International Announcement: WO2016/065142 WO 20160428
- Main IPC: A61K51/04
- IPC: A61K51/04 ; A61K41/00 ; A61K49/00 ; C07D213/82 ; C07D209/12 ; C07C271/22 ; C07C275/16 ; C07C323/62
Abstract:
Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.
Public/Granted literature
- US20170333576A1 NEW SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY Public/Granted day:2017-11-23
Information query
