An organic light emitting diode (OLED) display panel encapsulation structure includes a first inorganic layer, a first organic layer and a second inorganic layer stacked with one another. The organic layer is an ambipolar layer and the ambipolar layer is made of organic copolymer. Molecules of the organic copolymer have hydrophilic groups and hydrophobic groups. The present invention further provides an OLED display device including a substrate, a thin-film transistor driver layer, an OLED luminescent layer, and an OLED display panel encapsulation structure.