The present application discloses a method and system for interactive transmission of panoramic video, wherein the method comprises: determining, by a client, the location information of a user's current region of interest; requesting a server for video information of the region of interest by using the location information; and, acquiring, by the server, a panoramic video slice corresponding to the region of interest according to the location information, and transmitting the panoramic video slice to the client. With the present invention, resource overhead and a delay of transmission of panoramic video can be reduced.