An instrument string cleaner adapted for cleaning the strings of a stringed instrument. The string cleaner includes a clamping mechanism that is adapted to securely connect with and hold onto the strings of a stringed instrument. The clamping mechanism includes a top arched plate and a bottom arched plate held together with a pin that extends the width of the top and bottom plates. A coil spring has the pin extending there through. The string cleaner is normally biased to a closed position by the coil spring where the top and bottom arched plates are pressed against each other. The string cleaner has an open position where the top and bottom arched plates are spaced from each other. A first cleaning pad attached to the top arched plate, and second cleaning pad is attached to the bottom arched plate.