Systems, devices and methods for performing inventory management using RFID technology. The system includes a double-door box for receiving one or more items containing RFID tags. Items are scanned against a baseline content data to confirm all items are present and whether any items have expired. The box has security features to prevent unauthorized access to its contents and create an audit trail of access. Access to the box may be granted when two users present separate authorized RFID-enabled cards, wrist bands, or other items. Multiple locking features provide for additional security. A drop box mechanism on top of the housing allows for items to be deposited into the box without the same security protocols needed for accessing items. Scanning, authorization, and notification functions may be controlled remotely by an outside server or locally by a processing unit contained within the box itself.