Invention Grant
- Patent Title: Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
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Application No.: US15385490Application Date: 2016-12-20
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Publication No.: US10688200B2Publication Date: 2020-06-23
- Inventor: Hank F. Kung , Karl Ploessl , Seok Rye Choi , Zhihao Zha , Zehui Wu
- Applicant: Five Eleven Pharma Inc.
- Applicant Address: US PA Philadelphia
- Assignee: FIVE ELEVEN PHARMA INC.
- Current Assignee: FIVE ELEVEN PHARMA INC.
- Current Assignee Address: US PA Philadelphia
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K51/04
- IPC: A61K51/04 ; C07K5/02
Abstract:
The present invention relates to compounds according to Formula I and Formula IV. These compounds display very good binding affinities to the PSMA binding sites. They can be labeled with [68Ga]GaCl3 with high yields and excellent radiochemical purity. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula IV, or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20170189568A1 UREA-BASED PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITORS FOR IMAGING AND THERAPY Public/Granted day:2017-07-06
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