Invention Grant
- Patent Title: HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines
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Application No.: US16287559Application Date: 2019-02-27
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Publication No.: US10688173B2Publication Date: 2020-06-23
- Inventor: Sjoerd Henricus Van Der Burg , Gemma G. Kenter , Cornelis Johannes Maria Melief
- Applicant: Academisch Ziekenhuis Leiden H.O.D.N. LUMC
- Applicant Address: NL Leiden
- Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
- Current Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
- Current Assignee Address: NL Leiden
- Agency: Foley & Lardner LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@59e99444 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@479543c8
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C12N7/00 ; C07K14/005 ; A61K39/00 ; A61K38/00
Abstract:
The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.
Public/Granted literature
- US20190184002A1 HPV EPITOPES TARGETED BY T CELLS INFILTRATING CERVICAL MALIGNANCIES FOR USE IN VACCINES Public/Granted day:2019-06-20
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