Invention Grant
- Patent Title: Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies
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Application No.: US15538639Application Date: 2015-12-21
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Publication No.: US10688106B2Publication Date: 2020-06-23
- Inventor: Joan-Carles Arce
- Applicant: Ferring B.V.
- Applicant Address: NL Hoofddorp
- Assignee: FERRING B.V.
- Current Assignee: FERRING B.V.
- Current Assignee Address: NL Hoofddorp
- Agency: Choate, Hall & Stewart, LLP
- Agent Brenda H. Jarrell; Rolando Medina
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@175c1d8b
- International Application: PCT/NL2015/050893 WO 20151221
- International Announcement: WO2016/105190 WO 20160630
- Main IPC: A61K31/57
- IPC: A61K31/57 ; A61K31/404 ; A61B17/435 ; A61K38/095 ; A61K38/12 ; A61K45/06 ; A61K31/4045 ; A61K31/565 ; A61K9/00

Abstract:
The present invention relates to the use of an oxytocin receptor antagonist in females undergoing embryo transfer as part of an assisted reproductive technology. In particular, methods are provided for increasing ongoing implantation rate, increasing ongoing pregnancy rate, increasing clinical pregnancy rate, and/or increasing live birth rate in a female subject undergoing embryo transfer. Specifically, the antagonists are released in the luteal phase when the endometrium is receptive for embryo implantation and/or when the embryo has reached the blastocyst-stage.
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