The present disclosure provides a method and a device for processing voiceprint authentication. The method includes: extracting a first feature vector for each first speech segment of a training set by a gender-mixed voiceprint baseline system based on Deep Neural Network; training a gender classifier according to the first feature vector for each first speech segment and a pre-labeled first gender label of each first speech segment; training Deep Neural Network models for different genders respectively according to speech data of different genders of the training set; and training uniform background models, feature vector extracting models and linear probability discriminant analysis models for different genders respectively according to the Deep Neural Network models for different genders and the speech data of different genders of the training set. A voiceprint authentication processing model for gender distinguishing is built, thus improving the efficiency and accuracy of voiceprint authentication.