Invention Grant
- Patent Title: Method and apparatus to improve analytical method development and sample preparation for reproducible particle size measurement
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Application No.: US16321840Application Date: 2017-07-31
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Publication No.: US10684205B2Publication Date: 2020-06-16
- Inventor: Leandro Martins
- Applicant: Hovione Technology Ltd
- Applicant Address: IE County Cork
- Assignee: Hovione Technology Ltd
- Current Assignee: Hovione Technology Ltd
- Current Assignee Address: IE County Cork
- Agency: 24IP Law Group USA, PLLC
- Agent Timothy Dewitt
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@402a5bf2
- International Application: PCT/EP2017/069346 WO 20170731
- International Announcement: WO2018/024687 WO 20180208
- Main IPC: G01N15/02
- IPC: G01N15/02 ; G01N1/28 ; B06B1/02 ; G01N29/00 ; G01N15/14 ; G01N15/00 ; G01N1/40

Abstract:
A method and an apparatus to improve the precision and reproducibility of particle size analysis by laser diffraction is presented. Powder particles are typically prepared for laser diffraction testing using an ultra-sound bath which will disperse particle agglomerates and allow a precise measurement. However, the precision and reproducibility of agglomerate dispersion is affected by ultra-sound probe wear, corrosion and age. Differences in sonication performance can be compensated by voltage adjustments to the ultra-sound probe, leading to substantial improvements in the precision and reproducibility of particle size determination.
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