Invention Grant
- Patent Title: Clonal haematopoiesis
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Application No.: US15528807Application Date: 2015-11-23
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Publication No.: US10683552B2Publication Date: 2020-06-16
- Inventor: Steven Andrew McCarroll , Giulio Genovese
- Applicant: THE BROAD INSTITUTE INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: Presidents and Fellows of Harvard College,The Broad Institute, Inc.
- Current Assignee: Presidents and Fellows of Harvard College,The Broad Institute, Inc.
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Foley Hoag LLP
- International Application: PCT/US2015/062187 WO 20151123
- International Announcement: WO2016/085876 WO 20160602
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; A61K35/14 ; A61K35/28
Abstract:
The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.
Public/Granted literature
- US20170321284A1 CLONAL HAEMATOPOIESIS Public/Granted day:2017-11-09
Information query
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