Invention Grant
- Patent Title: Purine and 3-deazapurine analogues as choline kinase inhibitors
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Application No.: US16319951Application Date: 2017-07-19
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Publication No.: US10683292B2Publication Date: 2020-06-16
- Inventor: Elena Casale , Emiliana Corti , Paola Gnocchi , Marcella Nesi , Sten Christian Orrenius , Francesca Quartieri , Federico Riccardi Sirtori
- Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
- Applicant Address: IT Nerviano (MI)
- Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4cb45103
- International Application: PCT/EP2017/068255 WO 20170719
- International Announcement: WO2018/019681 WO 20180201
- Main IPC: C07D473/34
- IPC: C07D473/34 ; A61P35/00 ; C07D471/04 ; C07D473/40 ; C07D513/04 ; C07D513/14 ; C07D513/18
Abstract:
There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
Public/Granted literature
- US20190225615A1 PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS Public/Granted day:2019-07-25
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