Invention Grant
- Patent Title: Process for manufacturing 1-cyclopropyl-naphthalenes
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Application No.: US15736420Application Date: 2016-06-29
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Publication No.: US10683245B2Publication Date: 2020-06-16
- Inventor: Karl-Heinz Giselbrecht
- Applicant: PATHEON AUSTRIA GMBH & Co KG
- Applicant Address: AT Linz
- Assignee: Patheon Austria GMBH & Co. KG
- Current Assignee: Patheon Austria GMBH & Co. KG
- Current Assignee Address: AT Linz
- Agency: Pierce Atwood LLP
- Agent Raymond G. Arner
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@46e14c0
- International Application: PCT/EP2016/065201 WO 20160629
- International Announcement: WO2017/001516 WO 20170105
- Main IPC: C07C1/32
- IPC: C07C1/32 ; C07D231/06

Abstract:
A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula (1) wherein R1-R7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethylketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethylketone acid salt is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1H-pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190° C. to obtain the compound of Formula (1).
Public/Granted literature
- US20180186706A1 PROCESS FOR MANUFACTURING 1-CYCLOPROPYL-NAPHTHALENES Public/Granted day:2018-07-05
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