The invention relates to a bidirectional device for changing a handling glove from the inside towards the outside and from the outside towards the inside of a glove box under containment. The device is intended for replacing a used glove (60) with a new glove. The device comprises a cuff (6) sealingly connected to a cuff sleeve (20) and a glove (60) made of a flexible material sealingly connected to a glove sleeve (40). The glove sleeve comprises snap-fitting studs on the outside and the cuff sleeve comprises axial ramps (30). The snap-fitting studs of the glove sleeve slide in the axial ramps of the cuff sleeve until the glove sleeve is locked, forming, once assembled, a sealed assembly referred to as cuff port (10).