Dental implantation systems and methods are provided, including a site preparation device for preparing a site within a patient's mouth for receiving an anchor portion of a dental implant. An implant preparation device forms a crown portion of the dental implant for reception by the anchor portion. A guidance device communicates with a fiducial marker engaged with the patient's mouth, to interchangeably receive the site and implant preparation devices, and to guide the site and/or implant preparation device, relative to the fiducial marker, in conjunction with manipulation thereof by a user. A planning device communicates with and via the guidance device, and determines an arrangement of the dental implant at the site, to direct the site preparation device to prepare the site to receive the dental implant arrangement, and to direct the implant preparation device to prepare the crown portion for receipt by the anchor portion.