A multi-mode radio frequency (RF) circuit is provided. The multi-mode RF circuit is configured to support simultaneous communication in a pair of different frequency bands via an output node(s) coupled to an RF front-end circuit. A switchable filter circuit is configured to communicate one RF signal in a selected frequency band, while a multi-band filter circuit(s) is configured to communicate second RF signal in other frequency bands outside the selected frequency band. The switchable filter circuit is preconfigured to present various inherent impedances against each of the other frequency bands. A switching circuit is provided between the switchable filter circuit and the output node(s). In various operation modes, the switching circuit is configured to selectively provide one of the various inherent impedances to the output node(s), thus helping to mitigate interference caused by any of the other frequency bands used to support simultaneous communication with the selected frequency band.