Regulation systems and methods use a first regulator and a tracking second regulator. The first regulator receives a reference voltage and generates a first voltage output based upon the reference voltage, which is coupled as a back-bias voltage to a first load region within the integrated circuit. The first regulator also receives a sampled version of the first voltage output as feedback. A second regulator receives the first sampled voltage output and generates a second voltage output. The second regulator also receives a sampled version of the second voltage output as feedback. During operation, the second voltage output tracks (e.g., by a symmetry ratio) the first voltage output and is coupled as a back-bias voltage to a second load region within the integrated circuit. Further, switched-capacitor operation can be implemented, and clock frequency can be adjusted based upon the first sampled voltage output to reduce power consumption.