The disclosed computer-implemented method for detecting suspicious voice calls may include (i) identifying an incoming voice call, (ii) extracting, from audio of the incoming voice call, a plurality of characteristics, (iii) calculating a trustworthiness score of the plurality of the characteristics based on a response by a recipient of the incoming voice call, and (iv) storing the trustworthiness score of the plurality of characteristics in a reputation database that (a) receives a request for the trustworthiness score, the request originating from an additional computing device and including an additional plurality of characteristics extracted from an additional incoming voice call, (b) determines that the additional plurality of characteristics matches the plurality of characteristics, and (c) enables the additional computing device to perform a security action on the additional incoming voice call by sending the trustworthiness to the additional computing device. Various other methods, systems, and computer-readable media are also disclosed.