This application provides a drive circuit of a display device and a driving method for the display device. The display device includes a driver module and a display panel. The drive circuit includes: N single-ended to differential modules, connected to N signal output lines of the driver module and 2N scanning lines of the display panel and connected to a clock signal. Each single-ended to differential module is correspondingly connected to one signal output line and two scanning lines. The N single-ended to differential modules are configured to: output, to the 2N scanning lines according to the clock signal, scanning signals output by the N signal output lines, and charge the 2N scanning lines by using the N signal output lines, where N≥1, and N is a positive integer.