To that end, in order to overcome some of the deficiencies presented herein above, an exemplary system, method and computer-accessible medium for determining an attribute(s) of a brain of a patient, can include, for example, receiving information obtained from a computed tomography (“CT”) scan(s) of a portion(s) of the brain, generating a CT image(s) that can be based on the information, and determining the attribute(s) of the brain based on the CT image(s) by segmenting an intracranial space (ICS) in the CT image(s). The attribute(s) can include a presence or absence of Alzheimer's disease, total volume of the ICS, brain, CSF or a lesion or the volumes of ICS, brain, CSF or lesion(s) expressed as a percentage of other volume(s). The aforementioned areas can be segmented using a combination of thresholding, morphological erosions, morphological dilations, manual segmentation or semi-automatic segmentation techniques, all of which can be parallel procedures. These attributes can be further used to determine treatment, for example, optimizing the location of the twist drill craniotomy to drain hematoma in subdural hematoma.