Drone-based systems and methods for conducting a modified inspection of a delivery vehicle are described. A system has a delivery vehicle transceiver and an inspection drone paired to the vehicle that aerially inspects the vehicle. The delivery vehicle transceiver has a user interface and a wireless radio, while the paired inspection drone has a housing, onboard controller, memory storage, lifting engines, and a communication interface. The drone's onboard controller is operative to identify different existing delivery vehicle inspection points from an inspection profile record; receive an inspection update message from the communication interface; update the existing delivery vehicle inspection points with additional inspection points to yield a targeted inspection points corresponding to respective parts of the delivery vehicle; and conduct the modified inspection of the delivery vehicle by gathering the detected sensor-based inspection information related to each of the targeted inspection points.