The present invention relates to a method of guiding and controlling an unmanned aerial system based on camera control information of the unmanned aerial system, the method comprising the steps of: (a) controlling a vertical axis of the unmanned aerial system by controlling a zoom of a gimbal camera 330 by a zoom controller 120 of a camera control unit 100 so as to control an elevation and speed of the unmanned aerial system 300 with a corresponding camera control signal; and (b) controlling a horizontal axis of the unmanned aerial system by controlling an angle of the gimbal camera 330 by an angle controller 110 of the camera control unit 100. Accordingly, the present invention is applicable by just modifying software without changing a general system of an unmanned aerial system, has an advantage that a camera controller is enough to control a mission flight of the unmanned aerial system, and is improved in convenience and tracking performance since the speed, elevation, flight path, etc. of the unmanned aerial system are automatically controlled when a camera is used to continuously track a specific target.