Invention Grant
- Patent Title: Nanopore-based determination of protein charge, sharp, volume, rotational diffusion coefficient, and dipole moment
-
Application No.: US16436591Application Date: 2019-06-10
-
Publication No.: US10656117B2Publication Date: 2020-05-19
- Inventor: Michael Mayer , Erik Yusko
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Harness, Dickey & Pierce, P.L.C.
- Main IPC: G01N27/447
- IPC: G01N27/447 ; G01N33/487 ; C12Q1/6869
Abstract:
Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.
Public/Granted literature
Information query
