Invention Grant
- Patent Title: Histone acetyltransferase activators and compositions and uses thereof
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Application No.: US15655583Application Date: 2017-07-20
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Publication No.: US10653648B2Publication Date: 2020-05-19
- Inventor: Owen Anthony O'Connor , Jennifer Effie Amengual , Donald W. Landry , Ottavio Arancio , Luigi Scotto , Shixian Deng , Rosa Purgatorio , Jole Fiorito
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: A61K31/167
- IPC: A61K31/167 ; A61K31/5377 ; A61K31/44 ; A61K31/381 ; A61K45/06 ; A61K31/535 ; A61K31/4409 ; A61K31/495 ; A61K31/505 ; A61K31/18 ; A61K31/4035 ; A61K31/4453 ; A61K38/15
Abstract:
The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.
Public/Granted literature
- US20180021273A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF Public/Granted day:2018-01-25
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