- Patent Title: Method for preparing water extract of ashwagandha leaves which has enhanced anti-cancer activity utilizing cyclodextrin, and pharmaceutical composition containing ashwagandha leaves
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Application No.: US15115345Application Date: 2015-01-29
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Publication No.: US10646532B2Publication Date: 2020-05-12
- Inventor: Renu Wadhwa , Sunil Kaul
- Applicant: National Institute of Advanced Industrial Science and Technology , Cyclochem Co., Ltd.
- Applicant Address: JP Tokyo JP Ibaraki
- Assignee: National Institute of Advanced Industrial Science and Technology,Kaul-Tech Co., Ltd.
- Current Assignee: National Institute of Advanced Industrial Science and Technology,Kaul-Tech Co., Ltd.
- Current Assignee Address: JP Tokyo JP Ibaraki
- Agency: McCarter & English, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@19d0cfe6 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@fa42c8a
- International Application: PCT/JP2015/052431 WO 20150129
- International Announcement: WO2015/115512 WO 20150806
- Main IPC: A61K36/81
- IPC: A61K36/81 ; A61K47/40 ; A61K9/08 ; A61K9/16
Abstract:
It is an object of the present invention to provide a method for preparing a water extract of ashwagandha, which comprises increasing the amounts of withanone and withaferin A contained as active ingredients in the water extract of ashwagandha leaves. In addition, it is another object of the present invention to more economically and simply provide a pharmaceutical composition comprising ashwagandha leaves.The present invention relates to a method for preparing a water extract of ashwagandha leaves, which comprises extracting ashwagandha leaves with water in the presence of cyclodextrin, and a method for enhancing the anticancer activity of the water extract of ashwagandha leaves. The present invention also relates to a pharmaceutical composition for treating or preventing cancer, comprising the water extract of ashwagandha leaves. The present invention further relates to a pharmaceutical composition comprising dry powders of ashwagandha leaves and cyclodextrin.
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