The present disclosure relates to a Mura compensation method, including: obtaining a first image, obtaining an initial Mura compensation value M0 of each Mura pixel, determining whether the initial Mura compensation value M0 satisfies a relation −N≤M0≤N, configuring the initial Mura compensation value as a target Mura compensation value, determining whether a maximum value M1 and a minimum value M2 satisfy a relation M2>0, N 0, N