An ear interface mode of headphones may be determined by measuring an acoustic response of the headphones. For example, the headphones may be determined to be in a leaky or sealed configuration. An adaptive noise cancellation (ANC) system may be controlled based on the determined ear interface mode of the headphones. For example, a set of configuration parameters may be loaded for the ANC system corresponding to the known ear interface mode. An anti-noise signal may be generated according to the selected configuration parameters, and that anti-noise signal added during playback of media, such as voice recordings, music, videos, or telephone call speech.