A hybrid trip planning system can receive transport requests from requesting users, and determine a pick-up location from each transport request. The pick-up location can be within or external to an autonomy grid on which a plurality of autonomous vehicles (AVs) can operate in an autonomous mode. The system can further determine a drop-off location from the transport request, the drop-off location also being within or external to the autonomy grid. The system can select and route an AV to a most optimal entry and/or exit point of the autonomy grid based on the transport request, where the selected AV is to switch between a manual and an autonomous mode.