Systems and methods described herein are directed to techniques for selective TCP spoofing of a TCP connection between a first and a second host based on spoofing resource conditions and characteristics of the hosts involved in the TCP connection. In implementations, spoofing resource conditions may be based on a percentage of available resources in use by each of a TCP spoofer and a TCP spoofer peer. In implementations, characteristics of the hosts may be determined by tracking i) each TCP connection application type seen for each host over a time window; and ii) packet loss conditions of local hosts over a time window.