The invention concerns a fuel cell (100), comprising a stack (1) of alternating bipolar plates (113) and membrane electrode assemblies (114) as well as flow channels (104, 105) that are designed between a bipolar plate (113) and a membrane electrode assembly (114) and flow channels (104, 105) that are designed within a bipolar plate (113) as well as a motor vehicle with such a fuel cell. Provision is made that a surface (101) of at least a part of the flow channels (104, 105) that is overflowable by a fluid has, regarding its direction of extension at least in part a hydrophobic segment (101a) and a hydrophilic segment (101b) with regard to a cross-section of the flow channel (104, 105).