A method and apparatus for estimating or measuring a physical area or physical volume of an object of interest in one or more images captured using an endoscope are disclosed. According to the present method, an object of interest in an image or images is determined. Also, the endoscope captures one or more structured-light images to derive distance information associated with the object of interest with respect to the camera of the endoscope. The physical area size or physical volume size of the object of interest is then determined based on the image or images, and the distance information.