Information handling system non-volatile random access memory (NVRAM) that stores operating system variables is managed to prevent a memory full condition by erasing selected portions of the NVRAM during operating system state transitions. If a first bank of NVRAM reaches a memory full condition threshold, active variables are copied to a second back of NVRAM and at least a portion of the first bank of NVRAM is erased during an operating system state transition from an on state to a reduced power and/or off state.