Invention Grant
- Patent Title: Methods and kits for identifying effector Treg cells
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Application No.: US14908633Application Date: 2014-07-30
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Publication No.: US10578619B2Publication Date: 2020-03-03
- Inventor: Guy Gorochov , Makoto Miyara
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
- Applicant Address: FR Paris FR Paris FR Paris
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6),ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6),ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
- Current Assignee Address: FR Paris FR Paris FR Paris
- Agency: W&C IP
- Priority: EP13306106 20130731
- International Application: PCT/EP2014/066332 WO 20140730
- International Announcement: WO2015/014871 WO 20150205
- Main IPC: G01N33/564
- IPC: G01N33/564 ; G01N33/569
Abstract:
The present invention relates to methods and kits for identifying effector regulatory T cells. In particular the present invention relates to use of CD15s as a biomarker for eTreg cells. The present invention also relates to a method for identifying effector Treg cells (eTreg) in a fluid sample comprising the steps of i) detecting the cell surface expression of CD4, CD25, CD127 and CD15s markers on the cell population contained in the fluid sample and ii) concluding that the cells expressing CD4, CD25, CD127 at low levels and CD15s are the effector Treg cells. The present invention also relates to a method for identifying effector Treg cells (eTreg) in a tissue sample comprising the steps of i) detecting the cell expression of CD4, CD25, Foxp3 and CD15s markers and ii) concluding that the cells expressing CD4, CD25, Foxp3 and CD15s are the effector Treg cells.
Public/Granted literature
- US20160169891A1 METHODS AND KITS FOR IDENTIFYING EFFECTOR TREG CELLS Public/Granted day:2016-06-16
Information query
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