Invention Grant
- Patent Title: Formation of N-protected 3,6-bis-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-N-protected amino ester intermediate
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Application No.: US15953817Application Date: 2018-04-16
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Publication No.: US10577331B2Publication Date: 2020-03-03
- Inventor: John J. Freeman , Otto Phanstiel , William Elliot Bay , Kelly Sullivan Kraft
- Applicant: MannKind Corporation
- Applicant Address: US CA Westlake Village
- Assignee: MANNKIND, CORP.
- Current Assignee: MANNKIND, CORP.
- Current Assignee Address: US CA Westlake Village
- Agency: Calfee, Halter & Griswold LLP
- Main IPC: C07D241/08
- IPC: C07D241/08 ; C07D241/04 ; C07D241/10
Abstract:
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
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