Invention Grant
- Patent Title: Method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains having controlled grain size distribution, and HPMCAS powder
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Application No.: US15104561Application Date: 2014-12-15
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Publication No.: US10562983B2Publication Date: 2020-02-18
- Inventor: Sung Hwan Bang , Ju Hee Shin , Jin Ryul Son , Kyung Yeol Park , Jeong Hee Chun , Ji Seon Jeong , Sang Youb Lee
- Applicant: LOTTE FINE CHEMICAL CO., LTD.
- Applicant Address: KR Ulsan
- Assignee: LOTTE FINE CHEMICAL CO., LTD.
- Current Assignee: LOTTE FINE CHEMICAL CO., LTD.
- Current Assignee Address: KR Ulsan
- Agency: Cantor Colburn LLP
- Priority: KR10-2013-0169404 20131231; KR10-2014-0177826 20141210
- International Application: PCT/KR2014/012307 WO 20141215
- International Announcement: WO2015/102265 WO 20150709
- Main IPC: C08B3/16
- IPC: C08B3/16 ; C08B13/00 ; C08B11/20
Abstract:
Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step).
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