An anchoring system secures a catheter to the body of a patient and arrests axial movement of the catheter without impairing fluid flow through the catheter. The anchoring system can include an anchor pad 12 that adheres to the patient's skin and supports a retainer. The retainer can include interengaging structure that moves the retainer between an open and a closed position. When in the open position, the retainer can receive a portion of the catheter and be subsequently moved to the closed position. The interengaging structure can allow the retainer 20 to receive catheters of various sizes. The retainer can include one or more retention mechanisms to further inhibit axial movement of the catheter relative to the retainer when the catheter is secured therein. The anchoring system can include a mount that allows the retainer to rotate relative to the anchor pad.