Invention Grant
- Patent Title: Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
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Application No.: US15109619Application Date: 2014-12-29
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Publication No.: US10561737B2Publication Date: 2020-02-18
- Inventor: Ulrich Brinkmann , Guy Georges , Olaf Mundigl , Jens Niewoehner
- Applicant: HOFFMANN-LA ROCHE INC.
- Applicant Address: US NJ Little Falls
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Little Falls
- Priority: EP14150092 20140103; EP14174045 20140626
- International Application: PCT/EP2014/079351 WO 20141229
- International Announcement: WO2015/101586 WO 20150709
- Main IPC: A61K47/54
- IPC: A61K47/54 ; A61K47/60 ; A61K47/64 ; A61K47/68 ; C07K16/16 ; C07K16/26 ; C07K16/28 ; C07K16/40 ; C07K16/44 ; C07K16/46
Abstract:
Herein is reported a bispecific antibody comprising a first binding specificity that specifically binds to a haptenylated payload and a second binding specificity that specifically binds to a blood brain barrier receptor.
Public/Granted literature
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