Invention Grant
- Patent Title: Treatment of cancer and inhibition of metastasis using hemoglobin beta subunit
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Application No.: US15312928Application Date: 2015-05-21
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Publication No.: US10561712B2Publication Date: 2020-02-18
- Inventor: Wuyuan Lu , Issac Witz , Shelly Maman
- Applicant: UNIVERSITY OF MARYLAND, BALTIMORE , RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Applicant Address: US MD Baltimore IL Tel Aviv
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,RAMOT AT TEL AVIV UNIVERSITY LTD.
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,RAMOT AT TEL AVIV UNIVERSITY LTD.
- Current Assignee Address: US MD Baltimore IL Tel Aviv
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/US2015/031996 WO 20150521
- International Announcement: WO2015/179657 WO 20151126
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/42 ; C07K7/08 ; C07K14/805 ; G01N33/574 ; G01N33/72 ; A61K38/17 ; C12N5/09 ; G01N30/22 ; G01N30/72 ; G01N30/88 ; G01N33/53 ; A61K38/16 ; G01N33/68
Abstract:
The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The beta subunit of human hemoglobin (HBB) has been found to have similar activity. Methods of using these proteins and fragments thereof in the treatment of cancer and inhibition of metastasis are provided, along with methods of screening a subject for micrometastases by detecting HBB in a biological sample.
Public/Granted literature
- US20170304410A1 TREATMENT OF CANCER AND INHIBITION OF METASTASIS USING HEMOGLOBIN BETA SUBUNIT Public/Granted day:2017-10-26
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