Invention Grant
- Patent Title: Treatment of autism
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Application No.: US15129068Application Date: 2015-03-24
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Publication No.: US10561665B2Publication Date: 2020-02-18
- Inventor: Bonnie M. Davis
- Applicant: SYNAPTEC DEVELOPMENT LLC
- Applicant Address: US FL Palm Beach Gardens
- Assignee: Synaptec Development LLC
- Current Assignee: Synaptec Development LLC
- Current Assignee Address: US FL Palm Beach Gardens
- Agency: Ladas & Parry LLP
- International Application: PCT/US2015/022220 WO 20150324
- International Announcement: WO2015/148487 WO 20151001
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D491/06

Abstract:
Autistic Spectrum Disorders (ASD) are a group of developmental disorders including autistic disorder, Asperger disorder and pervasive developmental disorder not otherwise specified which may be treated by use of a galanthamine analog wherein the hydroxy group of galantamine is replaced by a carbamate, carbonate or ester group and the methoxy group may be replaced by another alkoxy group of from two to six carbon atoms, a hydroxy group, hydrogen, an alkanoyloxy group or 2 to 10 carbon atoms, a benzoyloxy or substituted benzoyloxy group, a carbonate group of 1 to 10 carbon atoms or a carbamate group such as a mono alkyl or dialkyl or an aryl carbamate wherein the alkyl groups or aryl groups contain from 1 to 10 carbons; and the N-methyl group may be replaced by hydrogen, alkyl of 1 to 10 carbon atoms, benzyl, cyclopropylmethyl group or a substituted or unsubstituted benzoyloxy group. Galantamine mon-alkylcarbamates are particularly useful.
Public/Granted literature
- US20170173038A1 TREATMENT OF AUTISM Public/Granted day:2017-06-22
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