A medication management system includes a cabinet, at least one drawer unit, at least one positioning unit and at least one control unit. The at least one drawer unit has an engaging portion. The at least one positioning unit includes an engaging module that separably engages with the engaging portion of the at least one drawer unit, a drive module that is operable to disengage the engaging module from the engaging portion of the at least one drawer unit, and an actuator that actuates operation of the drive unit to disengage the engaging module from the engaging portion of the at least one drawer unit based on an opening signal. The control unit is electrically connected to the actuator for outputting the opening signal.