For each respective virtual machine (VM) of a plurality of VMs, a distributed computing system generates a unique Application Binary Interface (ABI) for an operating system for the respective VM, compiles a software application to use the unique ABI, and installs the operating system and the compiled software application on the respective VM. A dispatcher node dispatches, to one or more VMs of the plurality of VMs that provide a service and are in the active mode, request messages for the service. Furthermore, a first host device may determine, in response to software in the first VM invoking a system call in a manner inconsistent with the unique ABI for the operating system of the first VM, that a failover event has occurred. Responsive to the failover event, the distributed computing system fails over from the first VM to a second VM.