Embodiments of the disclosure include a multi-band radio frequency (RF) front-end circuit. When a first antenna transmits an RF transmit signal in an RF transmit band, a second antenna may receive the RF transmit signal as an interference signal. The multi-band RF front-end circuit includes multiple receive filters for receiving an RF receive signal in multiple RF receive bands. A selected receive filter among the multiple receive filters is opportunistically reconfigured to help suppress the interference signal. Specifically, a bandpass bandwidth of the selected receive filter is expanded to include at least a portion of the RF spectrum of the interference signal. By doing so, it is possible to shunt the interference signal to a ground through the selected receive filter. As a result, it is possible to reduce an adverse impact of the interference signal to improve RF performance of the multi-band RF front-end circuit.