A system for generating an alimentary instruction set based on vibrant constitutional guidance using artificial intelligence includes a diagnostic engine operating on at least a server and configured to receive at least a biological extraction from a user and generate a diagnostic output, based on the at least a biological extraction. The system includes a plan generation module operating on the at least a server, the plan generation module designed and configured to generate, based on the diagnostic output, a comprehensive instruction set associated with the user. The system is further configured to generate an alimentary instruction set associated with the user based on the comprehensive instruction set, wherein the alimentary instruction set is configured to interact with a plurality of processes and services based on components of the alimentary instruction set.