A method and system is provided for storing and analyzing clinical imaging data. The method includes obtaining patient images from two or more modalities, registering the images, determining position information of a voxel, calculating and assigning a quality metric for the voxel, storing the voxel information and at least one searchable header as imaging data in a computer memory, and modifying or maintaining treatment based on the imaging data. The system includes a memory and a processor, the processor configured to obtain images from two or more modalities, register and store the image set in memory, calculate a quality metric for a voxel in the image set, store the voxel quality metric with the image set in the memory, and modify or maintain treatment based on the calculated qualitative metric.