Invention Grant
- Patent Title: Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions
-
Application No.: US15557731Application Date: 2016-03-10
-
Publication No.: US10548864B2Publication Date: 2020-02-04
- Inventor: Kun Ping Lu , Xiao Zhen Zhou , Shuo Wei , Lijun Sun , Michelle Lynn Hall
- Applicant: Beth Israel Deaconess Medical Center, Inc. , Pinteon Therapeutics, Inc.
- Applicant Address: US MA Boston
- Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Clark & Elbing LLP
- International Application: PCT/US2016/021759 WO 20160310
- International Announcement: WO2016/145186 WO 20160915
- Main IPC: A61K31/196
- IPC: A61K31/196 ; A61K45/06 ; A61K31/122 ; A61K31/4152 ; A61K31/4166 ; A61K31/4192 ; A61K31/4245 ; A61K31/452 ; A61K31/5375 ; A61K31/203 ; A61K31/4196
Abstract:
The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.
Public/Granted literature
Information query
IPC分类:
